The Ecological Regulating Effect of Exopolysaccharides Produced by Bifidobacterium on Intestinal Microecological Imbalance

Xiaotong Wu, Pinglan Li, Qian Shen, Guo Rong Liu, Rihua Xu

Ekoloji, 2018, Issue 106, Pages: 859-865, Article No: e106139

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Abstract

The paper investigates the ecological effect of exopolysaccharides (EPS) produced by Bifidobacterium animalis RH on mice intestinal flora in terms of behavioral ecology. The Bifidobacterium produced two kinds of EPS, named as EPSa and EPSb. Five intestinal floras were detected to explore what role EPS plays in regulating intestinal floral and fighting against intestinal flora disturbance. After 14-days gavage, in comparison with control group, EPSa and EPSb remarkably increased the quantity of Bifidobacterium and Lactobacillus (P<0.05), reduced Clostridium perfringens quantity (P<0.05), while there was no significant ecological change in the quantity of Enterobacteriaceae and Enterococcus (P>0.05). That indicates that Bifidobacterium EPS is capable of regulate the intestinal flora of normal mice. On the 15th day, cyclophosphamide (CTX) is intraperitoneally injected to build mucous-injured mice models. EPSa and EPSb also significantly antagonized the decreasing numbers of Bifidobacterium and Lactobacillus (P<0.05) and increasing amounts of Clostridium perfringens, Enterococcus and Enterobacteriaceae (P<0.05) to resist the intestinal dysbacteriosis induced by large dose of CTX and maintain intestinal flora balance.

Keywords

behavioral ecology, Bifidobacterium, Exopolysaccharide, intestinal flora

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